Factors determining the development of post-traumatic pain and post-traumatic osteoarthritis

Injuries cause a systemic neurohumoral and behavioral response of the body, aimed at restoring damaged tissues correcting biomechanical disorders. However, in many cases, full-fledged repair is impossible – traumatic injury, inflammation that occurs against its background, degenerative processes (fibrosis, neoangiogenesis, heterotopic ossification) lead to severe structural changes progressive decrease functional ability. The most common complications trauma include chronic post-traumatic pain osteoarthritis (PTOA). These are interrelated (accompanied by stiffness dysfunction) 10–50% people who have suffered joint injury may indicate formation early (pre-radiological) stages PTOA. development typical PTOA observed 10–15 years after knee (in >30% patients). large joints more aggressive, often accompanied synovitis, requires arthroplasty on average earlier than primary osteoarthritis. Early diagnosis based analysis dynamics clinical manifestations (primarily pain), visualization structure (magnetic resonance imaging), as well study level biomarkers osteochondral destruction. As additional risk factors for PTOA, genetic features considered determine chronicity inflammation, pain, impaired cartilage bone tissue.